Folding@Home

Playstation3 is now a very powerful supercomputer.

"Project Epoc is a headset that uses a set of sensors to tune into electric signals naturally produced by the brain to detect player thoughts, feelings and expression. It connects wirelessly with all game platforms from consoles to PCs."

Spore:

...a simulation that
"ranges from the molecular phase to the galactic phase"
[DICE 2007 Summit speech]